Precautions
What's another name for verapamil? BRAND NAME(S): Calan , Isoptin . USES: Verapamil is used with or without other medications to treat high blood pressure (hypertension).
Is verapamil an opiate?
verapamil systemic. Brand names: Calan, Verelan, Isoptin, Calan SR. Drug class (es): calcium channel blocking agents, group IV antiarrhythmics. Verapamil systemic is …
Is verapamil a statin drug?
Apr 01, 2022 · Description and Brand Names. Drug information provided by: IBM Micromedex. US Brand Name. Calan; Calan SR; Covera-HS; Isoptin SR; Verelan; Verelan PM; Descriptions. Verapamil is used alone or together with other medicines to treat heart rhythm problems, severe chest pain (angina), or high blood pressure (hypertension).
Is verapamil a diuretic?
Mar 16, 2022 · Verapamil is available under the following different brand names: Isoptin SR, Calan SR, Covera HS, Isoptin, Isoptin IV, Calan, Verap, Verapamil SR, Verelan, and Verelan PM. What Are Dosages of Verapamil?
What drug is Risperdal compared with?
Verapamil Tizanidine Sumatriptan Verapamil can help regulate the heart rate and lower blood pressure and is used to treat certain heart conditions. Constipation is the most common side effect of verapamil and it may interact with... more Tizanidine relieves muscle spasms but may cause sleepiness, a drop in blood pressure, and sedation.
What is the generic name for verapamil?
verapamil - oral, Calan, Isoptin.
Is verapamil and lisinopril the same?
Zestril (lisinopril) Lowers blood pressure and controls heart rate. Verapamil works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.
What is similar to verapamil?
Zanaflex.Emgality.Zolmitriptan.Imitrex.Galcanezumab.Indomethacin.
Are amlodipine and verapamil the same?
Conclusions: Verapamil is more effective in reducing blood pressure and rate-pressure product responses to stress compared with amlodipine. Although plasma noradrenaline is lower with verapamil at rest and after stress, the increase during stress is not different.
Can you take metoprolol and verapamil together?
verapamil metoprolol Using verapamil and metoprolol together may lead to increased side effects. This can cause fatigue, headache, fainting, swelling of the extremities, weight gain, shortness of breath, chest pain, increased or decreased heartbeat, or irregular heartbeat.
Is diltiazem a brand-name?
What is diltiazem? Diltiazem oral capsule is a prescription drug that's available as the brand-name drugs Cardizem CD and Taztia XT. Diltiazem oral tablet is available as the brand-name drug Cardizem. The extended-release form of diltiazem oral capsule is also available as a generic drug.
What's the difference between verapamil and diltiazem?
Verapamil has a more profound effect on gut smooth muscle than the other calcium channel antagonists. It reduces gut motility and causes constipation. Like verapamil, diltiazem is an arteriolar dilator which reduces peripheral resistance and thus blood pressure, but it is less cardio depressant.
What is substitute for calcium-channel blockers?
ACE inhibitors, sartans, alpha-blockers and thiazide diuretics are all possible alternatives.
Has verapamil been discontinued?
Mylan discontinued verapamil extended-release tablets in June 2021. Pfizer has Calan SR tablets on shortage due to manufacturing delay.Apr 11, 2019
Can you be on amlodipine and verapamil?
Verapamil or diltiazem in combination with amlodipine is an alternative for patients with a history of angioedema to an ACE inhibitor and for patients at increased risk of hyperkalemia.Jun 20, 2012
What is the difference between amlodipine and diltiazem?
Thus both amlodipine and diltiazem once-daily are effective in reducing blood pressure. While amlodipine is more potent than diltiazem in reducing systolic blood pressure, it causes more vasodilator side effects.
Can you take Norvasc and verapamil together?
verapamil amLODIPine You may be more likely to experience serious side effects such as irregular heart rhythm, fluid retention, swelling, heart failure, and excessively low blood pressure. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.
What is Verapamil used for?
Verapamil, sold under various trade names, is a calcium channel blocker medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia. It may also be used for the prevention of migraines and cluster headaches.
What is the mechanism of Verapamil?
Verapamil's mechanism in all cases is to block voltage-dependent calcium channels. In cardiac pharmacology, calcium channel blockers are considered class-IV antiarrhythmic agents. Since calcium channels are especially concentrated in the sinoatrial and atrioventricular nodes, these agents can be used to decrease impulse conduction through the AV node, thus protecting the ventricles from atrial tachyarrhythmias. Verapamil is also a Kv voltage gated potassium channel blocker.
What are the symptoms of verapamil overdose?
Acute overdose is often manifested by nausea, weakness, slow heart rate, dizziness, low blood pressure, and abnormal heart rhythms . Plasma, serum, or blood concentrations of verapamil and norverapamil, its major active metabolite, may be measured to confirm a diagnosis of poisoning in hospitalized patients or to aid in the medicolegal investigation of fatalities. Blood or plasma verapamil concentrations are usually in a range of 50–500 μg/L in persons on therapy with the drug, but may rise to 1–4 mg/L in acute overdose patients and are often at levels of 5–10 mg/L in fatal poisonings.
How long does verapamil last?
Half-life is 5–12 hours (with chronic dosages). It is not cleared by hemodialysis. It is excreted in human milk. Because of the potential for adverse reaction in nursing infants, nursing should be discontinued while verapamil is administered.
How much verapamil is absorbed?
Pharmacokinetic details. More than 90% of verapamil is absorbed when given orally, but due to high first-pass metabolism, bioavailability is much lower (10–35%). It is 90% bound to plasma proteins and has a volume of distribution of 3–5 L/kg.
Why does verapamil cause angina?
This has led to their use in treating high blood pressure and angina pectoris. The pain of angina is caused by a deficit in oxygen supply to the heart. Calcium channel blockers like verapamil dilate blood vessels, which increases the supply of blood and oxygen to the heart.
When was verapamil approved?
Verapamil was approved for medical use in the United States in 1981. It is on the World Health Organization's List of Essential Medicines. Verapamil is available as a generic medication. Long acting formulations exist.
What is verapamil used for?
Verapamil is indicated to treat hypertension, to treat and prevent chest pain ( angina ), supraventricular arrhythmia and atrial fibrillation / flutter, chronic atrial fibrillation and paroxysmal supraventricular tachycardia, supraventricular tachycardia ( pediatric ), and tardive dyskinesia. Verapamil may also be used to treat Migraines.
What happens if you take beta blocker after a dose increase?
Hypotension (initially or after dose increases) Exacerbation of angina (during initiation of treatment, after dose increase, or after withdrawal of beta-blocker) Neuromuscular transmission defects; may exacerbate myasthenia gravis. Hepatic or renal impairment. Persistent progressive dermatologic reactions.
How much isotin SR?
Calan, Isoptin SR: 180 mg/day orally given in morning (120 mg/day initially if patient elderly or of small stature); for desired response, may be increased to 240 mg/day, then to 360 mg/day (either 180 mg every 12 hours or 240 mg in morning and 120 mg in evening)
Can you take verapamil while pregnant?
Pregnancy and Lactation. Use verapamil with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies are not available, or neither animal nor human studies were done. Verapamil is distributed in milk; nursing infant doses range from less than 0.01% to 0.1% of mother 's dose.
Does Verapamil have any interactions?
Verapamil has mild interactions with at least 129 different drugs. This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use.
Is verapamil safe for nursing?
The manufacturer suggests refraining from nursing (though the American Academy of Pediatrics committee states that verapamil is compatible with nursing)
Can sumatriptan be used for migraines?
View. more. Sumatriptan may be used to quickly relieve the symptoms of a migraine but may not be suitable for everyone including those with pre -existing cardiovascular conditions.
Does verapamil lower blood pressure?
Verapamil can help regulate the heart rate and lower blood pressure and is used to treat certain heart conditions. Constipation is the most common side effect of verapamil and it may interact with... Tizanidine relieves muscle spasms but may cause sleepiness, a drop in blood pressure, and sedation.
What is the generic name for Verapamil?
Verapamil (Calan) generic is a calcium channel blocker, prescribed for high blood pressure, chest pain, abnormal heart rhythm, and headache. It works by relaxing the blood vessels.#N#More Info about Verapamil
How to see the price of Verapamil?
To view the price of the drug, click on the brand name . The generic Verapamil is manufactured by one company. Medindia's drug directory has currently 19 Brands of Verapamil listed. New generics and brands are constantly being updated as and when they are approved by drug controller and available in the pharmacies.
What is the name of the disease that causes the penis to bend?
Hypertrophic cardiomyopathy (HCM) is an inherited disease of the heart muscle (myocardium). Peyronie's Disease. Peyronie''s disease is caused by scar tissue along the length of the penis, which causes the penis to bend during erection in men. Atrial Fibrillation.
What is the name of the condition that reduces blood supply to the hands and feet in smokers?
Buerger's Disease. Buerger's disease or thromboangiitis obliterans is a condition that reduces blood supply to the hands and feet in smokers. Thunderclap Headaches. Thunderclap headaches are severely painful headaches that peak within 60 seconds and occur without any apparent trigger.
Where is Verapamil located?
Verapamil is a calcium-channel blocker (antagonist) which decreases the entry of calcium ions through L-type calcium channels located in heart cells and smooth muscle cells of the peripheral vasculature. 3
What is Verapamil 1 used for?
Richard N. Fogoros, MD. Updated on November 17, 2019. Verapamil 1 is a potent medication used to treat heart disease. Because it dilates the blood vessels of the heart and body both, it has numerous clinical applications.
What is the class IV of verapamil?
Here are some of verapamil's uses: Verapamil is a class-IV antiarrhythmic drug. 11 Before physicians used verapamil to treat arrhythmias, propranolol and digoxin were often used.
How long does verapamil last?
6 On the first-pass metabolism, verapamil is broken down by the liver into an active metabolite. Verapamil's half-life is about eight hours.
Is verapamil a cardiologist?
Although rare under the close monitoring of a cardiologist, verapamil toxicity is always a concern. 12 In addition to its own adverse effects, verapamil can also interact with a wide variety of other drugs.
Does verapamil slow atrioventricular node conduction?
Slowed atrioventricular node conduction. In addition to the above effects, verapamil also interferes with the energy metabolism of cardiac cells , increasing the heart's dependence on carbohydrates rather than free fatty acids. 5 Moreover, verapamil inhibits pancreatic production of insulin.
Does grapefruit juice affect Verapamil?
Additionally, grapefruit juice also affects the P450 system and may increase verapamil blood concentrations. 15 . Please keep in mind that when used as advised and in a safe manner, verapamil can be of great benefit to those who need it.
Overview
Verapamil is used to treat high blood pressure.
May Treat: Hypertension · Unstable angina pectoris · Cardioversion of atrial fibrillation · Paroxysmal supraventricular tachycardia · Anginal pain from vasospastic angina and more
Brand Names: Calan · Isoptin · Calan SR · Verelan PM · Verelan and more
Drug Class: Antiarrhythmic - Class IV · Calcium Channel Blockers - Phenylakylamines
Availability: Prescription Required
Pregnancy: Consult a doctor before using
May Treat: Hypertension · Unstable angina pectoris · Cardioversion of atrial fibrillation · Paroxysmal supraventricular tachycardia · Anginal pain from vasospastic angina and more
Brand Names: Calan · Isoptin · Calan SR · Verelan PM · Verelan and more
Drug Class: Antiarrhythmic - Class IV · Calcium Channel Blockers - Phenylakylamines
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Does not adversely affect lactation
Alcohol: Limit intake while taking this medication
Driving: May cause drowsiness or dizziness. Use caution
- MD may need to reduce the dose before you stop it.
- May make you dizzy. Use caution when driving.
- Tell doctor your complete medical history
- MD may need to reduce the dose before you stop it.
- May make you dizzy. Use caution when driving.
- Tell doctor your complete medical history
- Review all drugs you are taking with your doctor
- Check pulse and blood pressure. Share with MD.
- Swallow capsules whole.
- For capsule, extended release pellets 24 hr products : Take at the same time every day. Do not chew or crush. May open capsule. Mix into cool applesauce & swallow.
- For tablet products : Reduce or avoid drinking alcohol. Tell doctor/surgeon on drug prior to any surgery. Lab tests may be ordered to monitor therapy.
- For tablet, extended release products : Do not chew or crush.
Medical uses
Contraindications
Side effects
Mechanism of action
Verapamil, sold under various trade names, is a calcium channel blocker medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia. It may also be used for the prevention of migraines and cluster headaches. It is given by mouth or by injection into a vein.
Pharmacokinetic details
Verapamil is used for controlling ventricular rate in supraventricular tachycardia and migraine headache prevention. It is a class-IV antiarrhythmic and more effective than digoxin in controlling ventricular rate. Verapamil is not listed as a first line agent by the guidelines provided by JAMA in JNC-8. However, it may be used to treat hypertension if patient has co-morbid atrial fibrillationor other typ…
Veterinary use
Use of verapamil is generally avoided in people with severe left ventricular dysfunction, hypotension (systolic blood pressure less than 90 mm Hg), cardiogenic shock, and hypersensitivity to verapamil. It is also contraindicated in people with atrial flutter or fibrillation and an existing accessory tract such as in Wolff-Parkinson-White syndrome.
Uses in cell biology
The most common side effect of verapamil is constipation (7.3%). While the definite mechanism by which Verapamil causes constipation has not been studied, studies have been conducted to rule out mechanisms of actions that might yield this adverse effect. In a study conducted by The National Library of Medicine titled, "Effect of Verapamil on the Human Intestinal Transit", the study found that verapamil does not have an effect on upper GI transit but rather in the colon.