What is the most important factor in determining what causes the placental barrier?
The primary determining factors of what type of drugs will cross the placental barrier are molecular weight, lipid (fat or fat-like) solubility, polarity (molecular charge), protein binding, and receptor mediation.
What crosses the placental barrier?
Lead, cobalt, arsenic and selenium appear to pass the placental barrier by a diffusion mechanism. It was also found that the mercury levels in cord blood were almost double those of the mother, suggesting that the foetus may act as a filter for the maternal mercury levels during pregnancy.
What are the factors that influence drug transfer across placenta?
Nutrient and drug transfer across the placenta are by passive diffusion, facilitated diffusion, active transport, and pinocytosis. Placental drug transfer is dependent on the physical properties of the placental membrane and on the pharmacological properties of the drug.
What may pass through the placental barriers?
Other substances that pass through the placenta include red blood cell antigens, carbon dioxide, oxygen, some viruses, and nutrients.
What is able to pass across the placenta between the embryo fetus during pregnancy?
Oxygen and nutrients from the mother's blood are transferred across the placenta to the fetus through the umbilical cord.
Which of the following Cannot pass through the placenta quizlet?
Bacteria and most viruses cannot pass the placental barrier.
Does protein cross the placenta?
Conclusions: The correlation between maternal and fetal concentrations of various proteins like IgA (150,000 Da), hCG (42,000 Da), and hPL (21,000 Da) suggests passive diffusion of these macromolecules across the placenta from the maternal to the fetal side, albeit at a slow rate.
How do most drugs cross the placenta?
It has been shown that that nearly all drugs that are administered during pregnancy will enter, to some degree, the circulation of the foetus via passive diffusion. In addition, some drugs are pumped across the placenta by various active transporters located on both the fetal and maternal side of the trophoblast layer.
What is the main function of the placenta quizlet?
What is the function of the placenta? It allows oxygen and nutrients to pass from the mother to the fetus, and bodily wastes to pass from the fetus to the mother.
Which of the following Cannot pass through placental barriers?
Blood cells cannot pass through the placental barriers. The movement of blood cells from baby to mother or mother to baby can be fatal since they might have different blood types.
What comprises the placental membrane quizlet?
The result is a placental membrane composed of syncytiotrophoblast and the endothelium of the fetal capillaries.
How do you know when the placenta takes over?
Over the course of your pregnancy, the placenta grows from a few cells into an organ that will eventually weigh about 1 pound. By week 12, the placenta is formed and ready to take over nourishment for the baby. However, it continues to grow throughout your pregnancy. It's considered mature by 34 weeks.
Which of the following Cannot pass through placental barriers?
Blood cells cannot pass through the placental barriers. The movement of blood cells from baby to mother or mother to baby can be fatal since they might have different blood types.
Which antibody can pass placenta?
IgG is the only antibody class that significantly crosses the human placenta. This crossing is mediated by FcRn expressed on syncytiotrophoblast cells.
Can blood cells cross the placenta?
During pregnancy, red blood cells from the unborn baby can cross into the mother's blood through the placenta. If the mother is Rh-negative, her immune system treats Rh-positive fetal cells as if they were a foreign substance. The mother's body makes antibodies against the fetal blood cells.
Do antibodies cross placenta?
Placental transfer of maternal IgG antibodies to the fetus is an important mechanism that provides protection to the infant while his/her humoral response is inefficient. IgG is the only antibody class that significantly crosses the human placenta.