Precautions
– On an empty stomach (2 hours after a meal or 1 hour before a meal). – With 8 ounces of water. Do not take it with any other liquid. What if I miss a dose? If you miss a dose, call the phone number for your doctor’s team (see the “Questions” box on page 3). Tell the nurse that you missed a dose and ask what to do. Are there any safety concerns?
How long before a meal should you take ondansetron?
What Does Odt Mean On A Prescription? Disintegrating Tablets That Can Be Orally Disintegrated – A Dosage Form Specially Designed To Help Out Patient Populations That Cannot Reseal Tablets.
What does it mean when medications say ODT?
Speak to your doctor about how drug interactions should be managed. Common medications that may interact with ondansetron include: antidepressants, such as tricyclic antidepressants (eg, amitriptyline), monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine), venlafaxine, and SSRIs (eg, citalopram, paroxetine, sertraline)
Does ondansetron ODT interact with other medications?
Zofran’s dosage can vary depending on the severity and cause of nausea and vomiting. Is It Ok To Split Pills In Half? The only way to split pills is in half, not in any smaller ones. It is too likely that the dose per piece will be uneven, and pills may shatter or crumble if they are taken. Half-baked. Unequal halves.
Can you break Zofran ODT in half?
Does ondansetron dissolve under tongue?
For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults—24 milligrams (mg) or three 8-mg films taken 30 minutes before starting cancer treatment. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor.
Can you take ondansetron ODT on an empty stomach?
Ondansetron can be taken with or without food. However, it works faster on an empty stomach, an hour before food, or 2 hours after meals. The first dose of Ondansetron is usually taken before the start of your surgery, chemotherapy, or radiation treatment.
When should I take ondansetron ODT?
Your Zofran ODT dosing may then continue for one to two days after treatment is finished. To prevent nausea and vomiting after surgery, people usually take Zofran ODT one hour before the start of general anesthesia. As with any drug, it's essential to take Zofran ODT exactly as prescribed by your healthcare provider.
Do you let ondansetron dissolve?
Allow it to dissolve completely, then swallow it with saliva. You do not need to take this product with water. Doing so may increase your chance of getting a headache. To prevent nausea from chemotherapy, take this medication usually within 30 minutes before treatment begins.
What happens if you swallow an ODT tablet?
Alternatively, ODTs may be swallowed whole. > Once disintegrated, an easy-to-swallow residue is left behind and the medication will be absorbed from the gastrointestinal tract.
What can you not take with ondansetron?
Some products that may interact with this drug are: apomorphine, tramadol. Many drugs besides ondansetron may affect the heart rhythm (QT prolongation), including dofetilide, pimozide, procainamide, amiodarone, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others.
What is a common side effect of ondansetron?
confusion. nausea, vomiting, or diarrhea. loss of coordination. stiff or twitching muscles.
What happens if I throw up after taking Zofran?
Yes, you can still vomit after taking Zofran (ondansetron). Zofran (ondansetron) is used for the prevention of nausea and vomiting. If you're actively vomiting, it will not work to stop you from throwing up. If you continue to vomit after taking Zofran (ondansetron) you should inform your healthcare provider.
Does 3 times a day mean every 8 hours?
One to be taken three times a day When the medicine label on the medicine says to take three times day it generally means 'take every 8 hours'. For example we divide 8 hours into 24 hours which gives us 3. Therefore four times a day would be 'every 6 hours,' (24 divided by 6 = 4).
Are you supposed to swallow fast dissolve tablets?
Swallowing quick-dissolve drugs is not advised, says Cynthia LaCivita, clinical affairs associate for the American Society of Health System Pharmacists, especially for drugs like selegilene that may come formulated as a lower than usual dose because little drug is lost in the G.I. tract.
How do you take ondansetron disintegrating 4 mg?
How should I take ondansetron?Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. ... Use dry hands to remove the tablet and place it in your mouth.Do not swallow the tablet whole. ... Swallow several times as the tablet dissolves.
How do I use ODT on my tablet?
How should I take Zofran ODT?Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. ... Use dry hands to remove the tablet and place it in your mouth.Do not swallow the tablet whole. ... Swallow several times as the tablet dissolves.
How long does ondansetron ODT take to work?
You can take ondansetron with or without food. It should start to work within 30 minutes to an hour. Ondansetron tablets are available in 2 different forms – tablets or oral disintegrating tablets (also called ODT). Tablets: Swallow the tablets with a glass of water.
Do I take Zofran before or after I eat?
Ondansetron can be taken with or without food. The first dose of ondansetron is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor's dosing instructions very carefully. Take the ondansetron regular tablet with a full glass of water.
What happens if I throw up after taking Zofran?
Yes, you can still vomit after taking Zofran (ondansetron). Zofran (ondansetron) is used for the prevention of nausea and vomiting. If you're actively vomiting, it will not work to stop you from throwing up. If you continue to vomit after taking Zofran (ondansetron) you should inform your healthcare provider.
Does ondansetron make you sleepy?
Ondansetron orally disintegrating tablet may cause drowsiness. It can also cause other side effects.
Before Taking Ondansetron
You should not use ondansetron if: 1. you are also using apomorphine (Apokyn); or 2. you are allergic to ondansetron or similar medicines (dolasetr...
How Should I Take Ondansetron?
Take ondansetron exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or sma...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Happens If I Overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include sudden loss of vision, severe constip...
What Should I Avoid While Taking Ondansetron?
Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Ondansetron Dosing Information
Usual Adult Dose of Ondansetron for Nausea/Vomiting -- Chemotherapy Induced:Oral:Highly Emetogenic Cancer Chemotherapy (HEC):-Recommended dose: 24...
What Other Drugs Will Affect Ondansetron?
Ondansetron can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, he...
What to know before taking Ondansetron?
Before taking ondansetron, tell your doctor if you have liver disease, or a personal or family history of Long QT syndrome.
What is ondansetron?
Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
How much cisplatin should I take for chemo?
Oral:#N#Highly Emetogenic Cancer Chemotherapy (HEC):#N#-Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC (including cisplatin doses of 50 mg/m2 or greater )#N#Moderately Emetogenic Cancer Chemotherapy (MEC):#N#-Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy#N#Parenteral:#N#-Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose.#N#-Maximum dose: 16 mg per dose#N#Comments:#N#-Multi-day, single-dose administration of 24 mg orally for HEC has not been studied.#N#-The injection formulation should be diluted prior to IV administration.#N#Uses:#N#-Prevention of nausea and vomiting associated with HEC or MEC#N#-Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy
How old do you have to be to take Ondansetron?
Ondansetron is not approved for use by anyone younger than 4 years old.
What are the side effects of Ondansetron?
Common ondansetron side effects may include: diarrhea or constipation; headache; drowsiness; or. tired feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How to take a tablet with a blister pack?
Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.
What is Ondansetron used for?
Ondansetron orally disintegrating tablets are indicated for the prevention of nausea and vomiting associated with: highly emetogenic cancer chemotherapy, including cisplatin greater than or equal to 50 mg/m 2. initial and repeat courses of moderately emetogenic cancer chemotherapy. radiotherapy in patients receiving either total body irradiation, ...
What is the primary pathway of ondansetron?
The primary metabolic pathway is hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation. In vitro metabolism studies have shown that ondansetron is a substrate for human hepatic cytochrome P-450 enzymes, including CYP1A2, CYP2D6, and CYP3A4.
What is the name of the tablet that is embossed with 5 on one side?
Ondansetron Orally Disintegrating Tablets USP, 4 mg are white to off-white, round tablets debossed with ‘5’ on one side and ‘E’ on the other side with an embossed circular edge.
What are the side effects of Ondansetron?
Hypotension (and faintness) occurred in a patient that took 48 mg of ondansetron tablets. Following infusion of 32 mg over only a 4-minute period, a vasovagal episode with transient second-degree heart block was observed. In all instances, the adverse reactions resolved completely.#N#Pediatric cases consistent with serotonin syndrome have been reported after inadvertent oral overdoses of ondansetron (exceeding estimated ingestion of 5 mg per kg) in young children. Reported symptoms included somnolence, agitation, tachycardia, tachypnea, hypertension, flushing, mydriasis, diaphoresis, myoclonic movements, horizontal nystagmus, hyperreflexia, and seizure. Patients required supportive care, including intubation in some cases, with complete recovery without sequelae within 1 to 2 days.
Can Ondansetron be used with Tramadol?
Although no pharmacokinetic drug interaction between ondansetron and tramadol has been observed, data from 2 small trials indicate that when used together, ondansetron may increase patient-controlled administration of tramadol. Monitor patients to ensure adequate pain control when ondansetron is administered with tramadol.
Does Ondansetron inhibit P-450?
Ondansetron does not itself appear to induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system of the liver [see Clinical Pharmacology (12.3)]. Because ondansetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes (CYP3A4, CYP2D6, CYP1A2), inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron. In patients treated with potent inducers of CYP3A4 (i.e., phenytoin, carbamazepine, and rifampin), the clearance of ondansetron was significantly increased and ondansetron blood concentrations were decreased. However, on the basis of available data, no dosage adjustment for ondansetron is recommended for patients on these drugs [see Clinical Pharmacology (12.3)].
Does Ondansetron cause nausea?
The use of ondansetron in patients following abdominal surgery or in patients with chemotherapy-induced nausea and vomiting may mask a progressive ileus and/or gastric distension. Monitor for decreased bowel activity, particularly in patients with risk factors for gastrointestinal obstruction.
What to do if someone collapses after taking Ondansetron?
If someone collapses or isn't breathing after taking ondansetron, call 911 immediately .
How to store Zofran ODT?
Store the Zofran ODT bottle or foil blister pack at room temperature or in the refrigerator. Be sure to keep your medication out of reach of children and pets.
What Are the Side Effects of Zofran ODT?
This is not a complete list of side effects, and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
What Is Zofran ODT?
Zofran ODT (ondansetron) is an antiemetic drug that helps prevent nausea and vomiting. This prescription medication dissolves on the top of your tongue and works by preventing a chemical called serotonin from reaching certain cells in the brain.
What Other Medications Interact With Zofran ODT?
When taken with Zofran ODT, several medications may increase your risk of developing serotonin syndrome. Along with Zofran ODT, if you are taking a medicine that increases serotonin levels in the body, your doctor may need to choose a different treatment or monitor you more closely.
What to do if you miss Zofran?
In that case, skip your missed dose and take your Zofran ODT at your regularly scheduled time.
What is the name of the drug that is similar to Zofran?
Two drugs that most closely resemble Zofran ODT are Anzemet (dolasetron) and the generic drug granisetron (the brand-name Kytril has been discontinued in the United States). These drugs also work by blocking the effects of serotonin in the body. 6
What is Ondansetron used for?
A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Antiemetics are drugs that reduce nausea and vomiting.
What to do if you have serious side effects?
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
How long after chemo can you take 8 mg?
Typical dosage for chemotherapy that’s somewhat likely to cause nausea and vomiting: 8 mg given 30 minutes before chemotherapy. Four and eight hours after the first dose, your child can take another 8 mg. For 1–2 days after chemotherapy, they can take 8 mg three times per day.
Does Ondansetron cause coma?
Serotonin syndrome warning: Ondansetron raises your risk of a life-threatening condition called serotonin syndrome. This syndrome occurs when the chemical serotonin builds up too much in your body. A high level of serotonin can cause agitation, delirium (confused thinking) and hallucinations (seeing or hearing things that aren’t real). It can also cause sweating, rapid heartbeat, muscle stiffness, tremor, seizures, jerky muscle movements, and coma. Call your doctor right away if you have any of these symptoms. This condition can result from using ondansetron alone. However, it’s more likely to occur when you’re also taking another drug that affects serotonin levels.
Is Ondansetron a generic drug?
Ondansetron orally disintegrating tablet is available as a brand-name drug and as a generic drug. Brand name: Zofran ODT.
Can you take Ondansetron with phenylketonuria?
This amino acid can cause dangerous effects in people with a condition called phenylketonuria. Don’t take the orally disintegrating tablet if you have phenylketonuria.
Can Ondansetron cause drowsiness?
Ondansetron orally disintegrating tablet may cause drowsiness. It can also cause other side effects.
What do I need to tell my doctor BEFORE I take Ondansetron Orally Disintegrating Tablets?
If you have an allergy to ondansetron or any other part of this medicine (ondansetron orally disintegrating tablets).
How is this medicine (Ondansetron Orally Disintegrating Tablets) best taken?
Use this medicine (ondansetron orally disintegrating tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
What to do if your symptoms don't get better?
If your symptoms or health problems do not get better or if they become worse, call your doctor.
What to do if you think you have an overdose?
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Can you take Ondansetron with any medication?
You must check to make sure that it is safe for you to take this medicine (ondansetron orally disintegrating tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
Can Ondansetron cause a fast heartbeat?
A type of abnormal heartbeat (prolonged QT interval) has happened with this medicine ( ondansetron orally disintegrating tablets). Sometimes, this has led to another type of unsafe abnormal heartbeat (torsades de pointes). Call your doctor right away if you have a fast or abnormal heartbeat, or if you pass out.
What is Zofran ODT?
Zofran ODT blocks the actions of chemicals in the body that can trigger nausea and vomiting.
What other drugs will affect Zofran ODT?
Zofran ODT can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with this medicine.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
How old do you have to be to take Zofran?
Zofran ODT is not approved for use by anyone younger than 4 years old.
What are the side effects of Zofran?
Zofran ODT side effects. Get emergency medical help if you have signs of an allergic reaction: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe constipation, stomach pain, or bloating; headache with chest pain and severe dizziness, fainting, ...
How to take a tablet with a blister pack?
Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.
How to measure liquid medicine?
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
How much cisplatin should I take for chemo?
Oral:#N#Highly Emetogenic Cancer Chemotherapy (HEC):#N#-Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC (including cisplatin doses of 50 mg/m2 or greater )#N#Moderately Emetogenic Cancer Chemotherapy (MEC):#N#-Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy#N#Parenteral:#N#-Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose.#N#-Maximum dose: 16 mg per dose#N#Comments:#N#-Multi-day, single-dose administration of 24 mg orally for HEC has not been studied.#N#-The injection formulation should be diluted prior to IV administration.#N#Uses:#N#-Prevention of nausea and vomiting associated with HEC or MEC#N#-Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy
How much IV nausea is recommended for a 12 year old?
Parenteral:#N#1 month to 12 years:#N#Less than 40 kg:#N#-Recommended dose: 0.1 mg/kg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)#N#40 kg and greater:#N#-Recommended dose: 4 mg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)#N#Use:#N#-Prevention of postoperative nausea and vomiting
How long before chemo do you give emetogenic chemotherapy?
Parenteral: -Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose. -Maximum dose: 16 mg per dose. Comments:
How long before chemo can you give 0.15 mg?
Parenteral: 6 months to 18 years: -Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy, and subsequent doses given 4 and 8 hours after the first dose. -Maximum dose: 16 mg (per dose)
How long does it take to take chemo?
4 to 11 years: -Recommended dose: 4 mg orally 3 times a day, with the first dose administered 30 minutes before the start of chemotherapy, and subsequent doses 4 and 8 hours after the first dose; then 4 mg orally 3 times a day (every 8 hours) for 1 to 2 days after the completion of chemotherapy. 12 years and older: ...
How to dissolve Ondansetron?
When taking orally disintegrating ondansetron tablets, peel back the foil (do not attempt to push the tablet through the foil). Allow the tablet to dissolve in your mouth without chewing.
What to do if Ondansetron makes you dizzy?
If ondansetron makes you dizzy or drowsy, do not drive or operate machinery while you are affected and avoid alcohol.
How does Ondansetron work?
Ondansetron treats and prevents nausea and vomiting by an unknown mechanism, possibly by a direct effect on the CTZ (the area of the brain associated with vomiting), the vagus nerve, or both. The neurotransmitter, serotonin, appears to play a role in ondansetron's effect.
How long does it take for Ondansetron to peak?
The peak effect of ondansetron is seen within 1.5-2 hours. The onset of the effect is faster with the wafer form of ondansetron.
What class is Ondansetron?
Ondansetron belongs to the class of medicines known as 5-HT3 receptor antagonists.
Is Ondansetron liquid or oral?
Oral ondansetron is available as a conventional tablet, orally disintegrating tablet, or an oral solution. Oral disintegrating tablets are not required to be administered with liquid.
Can you share Ondansetron with children?
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use ondansetron only for the indication prescribed.
