Precautions
When administered through a Y-site, Protonix I.V. is compatible with the following solutions: 5% Dextrose Injection, USP, 0.9% Sodium Chloride Injection, USP, or Lactated Ringer's Injection, USP. Midazolam HCl has been shown to be incompatible with Y-site administration of Protonix I.V.
What solutions are compatible with Protonix IV?
The intravenous line should be flushed before and after administration of PROTONIX I.V. for Injection with either 5% Dextrose Injection, USP, 0.9% Sodium Chloride Injection, USP, or Lactated Ringer's Injection, USP.
When should I Flush my IV line after taking Protonix?
PROTONIX I.V. 40 mg once daily does not raise gastric pH to levels sufficient to contribute to the treatment of such life-threatening conditions. Only for intravenous infusion; other parenteral routes of administration are not recommended. Reconstitute PROTONIX I.V. with 10 mL of 0.9% Sodium Chloride Injection, USP.
Can Protonix 40 mg be given once a day?
The active ingredient in PROTONIX® I.V. (intravenous pantoprazole sodium) for Injection is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole, a compound that inhibits gastric acid secretion.
What is the active ingredient in Protonix?
Is pantoprazole compatible with D5W?
Based on the fastest degradation rate, determined with 95% confidence, solutions of pantoprazole in concentrations ranging from 0.16 mg/mL to 0.80 mg/mL diluted in D5W can be stored for a maximum of 11 days at 4°C. This allows for up to 8 h additional storage at 23°C.
What is pantoprazole compatible with?
Octreotide and pantoprazole were physically compatible when the octreotide concentration was less than 1.5 μg/mL. Norepinephrine was physically compatible with all pantoprazole concentrations when the norepinephrine concentration was less than 13 μg/mL.
What do you mix IV Protonix with?
PROTONIX I.V. for Injection should be reconstituted with 10 mL of 0.9% Sodium Chloride Injection, USP, and further diluted (admixed) with 100 mL of 5% Dextrose Injection, USP, 0.9% Sodium Chloride Injection, USP, or Lactated Ringer's Injection, USP, to a final concentration of approximately 0.4 mg/mL.
Is Protonix compatible with potassium IV?
No interactions were found between potassium chloride and Protonix. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
What can you not take with Protonix?
Tell your doctor if you're taking any of these medicines before you start pantoprazole treatment:antifungal medicines such as itraconazole, ketoconazole, posaconazole and voriconazole.fluvoxamine, an antidepressant.methotrexate, a medicine used to treat cancer, psoriasis and rheumatoid arthritis.HIV medicines.More items...
What can you not take with pantoprazole?
Do not use pantoprazole together with medicines containing rilpivirine (eg, Complera®, Edurant®, Odefsey®).
Is pantoprazole compatible with Ringer's lactate?
When administered through a Y-site, PROTONIX I.V. for Injection is compatible with the following solutions: 5% Dextrose Injection, USP, 0.9% Sodium Chloride Injection, USP, or Lactated Ringer's Injection, USP.
How do you prepare pantoprazole IV?
Pantoprazole 80 mg (2 vials) IV: Mix medication in 20 mL 0.9% NS in a syringe and give IV push or via syringe infuser or in a 50 mL minibag. Solution is stable for 21 hours at room temperature. One 100 mL bag will last 5 hours.
How do you reconstitute Protonix IV?
Reconstitute PROTONIX I.V. with 10 mL of 0.9% Sodium Chloride Injection, USP. Further dilute with 100 mL of 5% Dextrose Injection, USP, 0.9% Sodium Chloride Injection, USP, or Lactated Ringer's Injection, USP, to a final concentration of approximately 0.4 mg/mL. Inspect the diluted PROTONIX I.V.
Can dextrose and potassium IV compatibility?
Do not administer Potassium Chloride in Dextrose Injection simultaneously with blood products through the same administration set because of the possibility of pseudo agglutination or hemolysis.
How do you know IV compatibility?
You can also check the IV compatibility of a single drug. Enter one drug and click “View compatibility.” The default compatibility result will display the solution compatibilities for the IV Drug searched. You can also view different drugs and solutions that are compatible by clicking the drop-down arrows.
Is pantoprazole compatible with KCL?
No interactions were found between pantoprazole and Potassium Chloride in Sodium Chloride. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Is pantoprazole the same as omeprazole?
Does Pantoprazole Work Better Than Omeprazole? Generally, pantoprazole and omeprazole are equally effective. Studies comparing pantoprazole and omeprazole have found pantoprazole as effective as omeprazole in treating GERD as well as treating stomach ulcers.
What is the best time to take pantoprazole?
Pantoprazole is best taken before breakfast or 30 to 60 minutes before a meal. If administering twice daily take the first dose before breakfast and the second dose before dinner. Delayed-release granules should be sprinkled on one teaspoonful of apple sauce or apple juice and then swallowed whole.
Can I take Pepcid with pantoprazole?
No interactions were found between pantoprazole and Pepcid AC.
Is it OK to take probiotics with pantoprazole?
Interactions between your drugs No interactions were found between Digestive Advantage Daily Probiotic and pantoprazole.
How often should I take Protonix?
The recommended adult dosage of PROTONIX I.V. is 80 mg intravenously every 12 hours. The frequency of dosing can be adjusted to individual patient needs based on acid output measurements. In those patients who need a higher dosage, 80 mg intravenously every 8 hours is expected to maintain acid output below 10 mEq/h. Daily doses higher than 240 mg or administered for more than 6 days have not been studied [see Clinical Studies (14)]. Transition from oral to intravenous and from intravenous to oral formulations of gastric acid inhibitors should be performed in such a manner to ensure continuity of effect of suppression of acid secretion. Patients with ZE Syndrome may be vulnerable to serious clinical complications of increased acid production even after a short period of loss of effective inhibition.
How long can admixed solution be stored?
The admixed solution may be stored at room temperature and must be used within 24 hours from the time of initial reconstitution. Both the reconstituted solution and the admixed solution do not need to be protected from light. Do not freeze the reconstituted solution. Two Minute Infusion.
How often should I take Protonix?
The recommended adult dosage of PROTONIX I.V. is 80 mg intravenously every 12 hours. The frequency of dosing can be adjusted to individual patient needs based on acid output measurements. In those patients who need a higher dosage, 80 mg intravenously every 8 hours is expected to maintain acid output below 10 mEq/h. Daily doses higher than 240 mg or administered for more than 6 days have not been studied [see Clinical Studies (14)]. Transition from oral to intravenous and from intravenous to oral formulations of gastric acid inhibitors should be performed in such a manner to ensure continuity of effect of suppression of acid secretion. Patients with ZE Syndrome may be vulnerable to serious clinical complications of increased acid production even after a short period of loss of effective inhibition.
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What is Protonix IV?
Protonix IV is a prescription medicine used to treat the symptoms of Erosive Esophagitis associated with GERD, short-term treatment of GERD, and Zollinger-Ellison Syndrome. Protonix IV may be used alone or with other medications. Protonix IV belongs to a class of drugs called Proton Pump Inhibitors. It is not known if Protonix IV is safe and ...
What are the side effects of Protonix IV?
Get medical help right away, if you have any of the symptoms listed above. The most common side effects of Protonix IV include: headache, diarrhea, redness, pain, or swelling at the injection site, nausea, abdominal pain,
What is the Cmax of pantoprazole?
Following the administration of PROTONIX I.V. for Injection, the serum concentration of pantoprazole declines biexponentially with a terminal elimination half-life of approximately one hour. In CYP2C19 extensive metabolizers [see CLINICAL PHARMACOLOGY] with normal liver function receiving a 40 mg dose of PROTONIX I.V. for Injection by constant rate over 15 minutes, the peak concentration (Cmax) is 5.52 ±1.42 mcg/mL and the total area under the plasma concentration versus time curve (AUC) is5.4 ±1.5 mcg• hr/mL. The total clearance is 7.6-14.0 L/h.
What is the effect of pantoprazole on gastric acid production?
This effect leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus. The binding to the (H +, K + )-ATPase results in a duration of antisecretory effect that persists longer than 24 hours for all doses tested (20 mg to 120 mg).
How long does it take to take 40 mg of pantoprazole?
The recommended adult dose is 40 mg pantoprazole given once daily by intravenous infusion for 7 to 10 days. Treatment with PROTONIX® I.V. (pantoprazole sodium) for Injection should be discontinued as soon as the patient is able to receive treatment with PROTONIX Delayed-Release Tablets or Oral Suspension.
Is pantoprazole sodium soluble in water?
Pantoprazole has weakly basic and acidic properties. Pantoprazole sodium is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n-hexane.
Does Protonix cause diarrhea?
Published observational studies suggest that PPI therapy like PROTONIX may be associated with an increased risk of Clostridium difficile associated diarrhea, especially in hospitalized patients. This diagnosis should be considered for diarrhea that does not improve [see ADVERSE REACTIONS ].
How long can you keep Protonix at room temperature?
The reconstituted solution may be stored for up to 24 hours at room temperature prior to intravenous infusion and does not need to be protected from light. PROTONIX I.V. for Injection should be administered intravenously over a period of at least 2 minutes.
How long does 40 mg pantoprazole last?
The recommended adult dose is 40 mg pantoprazole given once daily by intravenous infusion for 7 to 10 days.
How long does it take to take 40 mg of pantoprazole?
The recommended adult dose is 40 mg pantoprazole given once daily by intravenous infusion for 7 to 10 days. Safety and efficacy of PROTONIX I.V. for Injection as a treatment of patients with GERD and a history of erosive esophagitis for more than 10 days have not been demonstrated (see INDICATIONS AND USAGE ).
How long can pantoprazole sodium be stored?
Protect from light. The reconstituted product should not be frozen. The admixed solution may be stored at room temperature and must be used within 24 hours from the time of initial reconstitution.
Does Protonix raise pH?
PROTONIX I.V. 40 mg once daily does not raise gastric pH to levels sufficient to contribute to the treatment of such life-threatening conditions. Parenteral routes of administration other than intravenous are not recommended.
Severe Interactions
These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
Serious Interactions
These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
Moderate Interactions
These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.