Precautions
The usual starting dose of losartan potassium tablets is 50 mg once daily. The dosage can be increased to a maximum dose of 100 mg once daily as needed to control blood pressure [see Clinical Studies (14.1) ]. A starting dose of 25 mg is recommended for patients with possible intravascular depletion (e.g., on diuretic therapy).
What is the normal dosage for losartan?
Usual Adult Dose of Losartan for Diabetic Nephropathy: Initial dose: 50 mg orally once a day. Maintenance dose: 25 to 100 mg orally in 1 to 2 divided doses. Usual Adult Dose for Hypertension: Initial dose: 50 mg orally once a day. Maintenance dose: 25 to 100 mg orally in 1 to 2 divided doses.
What is a normal dose of losartan?
Usual Adult Dose for Hypertension. Initial dose: 50 mg orally once a day. Maximum dose: 100 mg orally once a day. Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks.
What is the highest dose of losartan?
A: Losartan can be taken once or twice a day. For once daily dosing, there are no absolute recommendations about taking it in the morning vs. night. For high blood pressure, some research suggests taking medicines at night reduces the risk of cardiovascular events in the morning. Check with your doctor for questions about timing. More ›
Should losartan be taken twice a day?
See more
Is losartan 25 mg effective?
In controlled clinical studies, once-daily administration of losartan to patients with mild to moderate essential hypertension produced statistically significant reductions in systolic and diastolic blood pressure.
What is the most losartan you can take in a day?
The starting dose is usually 0.7 milligram (mg) per kilogram (kg) of body weight per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 50 mg per day.
Can you take losartan twice a day?
Lisinopril and losartan manufacturer labels recommend twice-daily dosing (BID) if once-daily (QDay) is insufficient to lower blood pressure (BP).
How much does 50mg losartan lower blood pressure?
Losartan at 25 and 50 mg plus HCTZ produced marked reductions (−10 and −12.6 mm Hg) in SiSBP compared with the control group; these changes were both clinically and statistically significant (P≤. 01). Table 3 summarizes the changes in standing BP after 1 and 12 weeks of double-blind therapy.
Is it better to take losartan at night or morning?
Key takeaways: Losartan (Cozaar) is an angiotensin II receptor blocker used to treat high blood pressure. The best time for many people to take losartan is in the morning.
Does losartan lower blood pressure immediately?
Losartan starts to reduce high blood pressure after about 1 hour but it may take 3 to 6 weeks to fully take effect. If you have high blood pressure, you may not have any symptoms. In this case, you may not feel any different when you take losartan. This does not mean that the medicine is not working.
What should I avoid while taking losartan?
Losartan has caused significant increases in blood potassium levels. Potassium supplements, potassium-containing salt substitutes (No Salt, Morton Salt Substitute, and others), and even high-potassium foods (including Noni juice) should be avoided by those taking losartan, unless directed otherwise by their doctor.
Why do you take losartan at bedtime?
New research suggests that taking your blood pressure medication at bedtime may more effectively reduce your risk of illness or death due to heart and blood vessel disease. Timing of medication is important because blood pressure follows a daily rhythm. It rises higher during the day and falls at night when we sleep.
Does losartan affect sleep?
Sleep disorders were reported in clinical trials of losartan. Other medications that can cause insomnia include antiarrhythmics, beta blockers, steroids, SSRIs, stimulants, and medications that contain caffeine or alcohol.
How do you know if you're taking too much losartan?
If a person takes too much: If they take too much losartan, they may have symptoms such as: feeling like their heart is pounding. weakness. dizziness.
What happens if I take 2 100mg losartan?
If you accidentally take too many tablets, or a child swallows some, contact your doctor immediately. Symptoms of overdose are low blood pressure, increased heartbeat, possibly decreased heartbeat. If you accidentally miss a daily dose, just take the next dose as normal.
Is losartan hard on the kidneys?
There is a risk of acute kidney failure developing in people taking losartan.
How do you know if you're taking too much losartan?
If a person takes too much: If they take too much losartan, they may have symptoms such as: feeling like their heart is pounding. weakness. dizziness.
Does 100mg of losartan last 24 hours?
At 100 mg daily losartan does last the full 24 hours. If you take Losartan 50 mg in the morning, you may notice your blood pressure rises at night, because it's not covering you for a full 24 hours. Valsartan does provide 24-hour coverage with once-daily dosing.
What happens if you take a lot of losartan?
Sometimes, taking losartan for a long time can cause your kidneys not to work as well as they should. Your doctor will check how well your kidneys are working with regular blood tests.
What happens if I take 2 losartan by mistake?
If you accidentally take too many tablets, or a child swallows some, contact your doctor immediately. Symptoms of overdose are low blood pressure, increased heartbeat, possibly decreased heartbeat. If you accidentally miss a daily dose, just take the next dose as normal.
Before Taking This Medicine
You should not use losartan if you are allergic to it.If you have diabetes, do not use losartan together with any medication that contains aliskire...
How Should I Take Losartan?
Take losartan exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
Losartan Dosing Information
Usual Adult Dose of Losartan for Diabetic Nephropathy:Initial dose: 50 mg orally once a day.Maintenance dose: 25 to 100 mg orally in 1 to 2 divided...
What Other Drugs Will Affect Losartan?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with losartan, especially: 1. a diuretic or "...
What is losartan?
Losartan belongs to a group of drugs called angiotensin II receptor antagonists. It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.
How should I take losartan?
Take losartan exactly as prescribed by your doctor. Follow all directions on your prescription label . Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What other drugs will affect losartan?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with losartan , especially:
How long does it take for losartan to lower blood pressure?
Visit your doctor regularly. It may take 3 to 6 weeks of using losartan before your blood pressure goes down somewhat. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 3 weeks of treatment.
How long does it take for blood pressure to go down with losartan?
It may take 3 to 6 weeks of using losartan before your blood pressure goes down somewhat. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 3 weeks of treatment.
What is the purpose of Losartan?
Losartan is used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease. Losartan is used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.
What happens if you have high blood pressure?
High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.
Does Losartan cause heart failure?
This can damage the blood vessels of the brain , heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure may reduce the risk of strokes and heart attacks. Losartan is an angiotensin II receptor blocker (ARB).
Does Losartan help with blood pressure?
As a result, losartan relaxes the blood vessels. A lower blood pressure will increase the supply of the blood and oxygen to the heart. Losartan is also used to decrease the risk of stroke in patients with high blood pressure and enlargement of the heart.
Usual Adult Dose for Hypertension
HYPERTENSION: Hydrochlorothiazide 12.5 to 25 mg-Losartan 50 to 100 mg orally once a day Maximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a day Comments: -A patient whose blood pressure is not adequately controlled with hydrochlorothiazide or losartan monotherapy may be switched to hydrochlorothiazide 12.5 mg-losartan 50 mg orally once a day. -May increase dose if blood pressure remains uncontrolled after about 3 weeks. Use: Treatment of hypertension.
Renal Dose Adjustments
Mild to moderate renal dysfunction (CrCl 30 mL/min or greater): No adjustment recommended Severe renal dysfunction (CrCl less than 30 mL/min): Not recommended
Precautions
US BOXED WARNING: -FETAL TOXICITY: If pregnancy is detected, discontinue this drug as soon as possible.
Other Comments
Monitoring: -Patients with a history of angioedema (swelling of the face, lips, throat, and/or tongue) should be closely monitored. -Monitor serum electrolytes and renal function periodically. Patient advice: -Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible. -Encourage patients to report any lightheadedness that may occur during treatment initiation and to stop taking this drug until consulting a physician if syncope occurs. -Dehydration may lead to excess blood pressure reduction; inform patients to contact their healthcare provider if they experience excessive perspiration, vomiting, or diarrhea..
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
What is losartan used for?
As an angiotensin II receptor blocker, losartan helps your blood vessels to relax in order to lower your blood pressure and make it easier for your heart to pump blood through your body.
How to store losartan?
Keep losartan in a tightly closed container that protects the medication from light. It should be stored at a temperature between 59 F and 86 F (between 15 C and 30 C). Keep it out of the reach of children. 7
What is the best blood pressure medication for high blood pressure?
Uses. Losartan is FDA-approved to lower blood pressure that is too high, meaning that you have a systolic pressure in your arteries (when your heart is beating) of 130 mm Hg or higher or a diastolic pressure (between heartbeats) of 80 mm Hg or higher. 2 .
How is Losartan taken?
Losartan is typically taken by mouth in the following dosages, according to the condition being treated. 7
Why was Losartan recalled?
Losartan was among a number of drugs subject to FDA recalls between 2018 and 2020 because they were found to contain unacceptably high levels of a nitrosamine, a potentially cancer-causing substance. 10 The impurities are thought to have been introduced during the manufacturing process.
Does Losartan block angiotensin II?
Losartan helps to block those actions by angiotensin II in people with hypertension. 4 . This is among the reasons why researchers looking into losartan for treating COVID-19 patients, though there isn’t enough data yet to confirm its effectiveness.
What causes yellowish skin?
Jaundice: Skin turns yellowish. Inflamed pancreas: Severe stomach pain is a symptom. Blood or bone marrow disorders: Fatigue, fever, paleness or purple spots may be signs. Changes in the sodium and potassium levels in your blood: Can cause muscle cramps or irregular heartbeat.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
What are the effects of Losartan on the renin-angiotensin system?
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Losartan as soon as possible. These adverse outcomes are usually associated with use of these drugs in the second and third trimester of pregnancy. Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus.
How long does it take for Losartan to work?
The effect of Losartan is substantially present within one week but in some studies the maximal effect occurred in 3 to 6 weeks. In long-term follow-up studies (without placebo control) the effect of Losartan appeared to be maintained for up to a year. There is no apparent rebound effect after abrupt withdrawal of Losartan. There was essentially no change in average heart rate in Losartan-treated patients in controlled trials.
What is Losartan 25 mg?
Losartan potassium tablets USP, 25 mg are white to off-white, capsule-shaped, film-coated tablets debossed with the logo of "Z" on one side and "2"on other side .
How to make Ora Plus?
Add 10 mL of Purified Water USP to an 8 ounce (240 mL) amber polyethylene terephthalate (PET) bottle containing ten 50 mg Losartan potassium tablets. Immediately shake for at least 2 minutes. Let the concentrate stand for 1 hour and then shake for 1 minute to disperse the tablet contents. Separately prepare a 50/50 volumetric mixture of Ora-Plus™ and Ora-Sweet SF™. Add 190 mL of the 50/50 Ora-Plus™/Ora-Sweet SF™ mixture to the tablet and water slurry in the PET bottle and shake for 1 minute to disperse the ingredients . The suspension should be refrigerated at 2 to 8°C (36 to 46°F) and can be stored for up to 4 weeks. Shake the suspension prior to each use and return promptly to the refrigerator.
What is the purpose of Losartan potassium?
Losartan potassium tablets are indicated for the treatment of hypertension in adults and pediatric patients 6 years of age and older, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and nonfatal cardiovascular (CV) events, primarily strokes and myocardial infarction.
What are the effects of oligohydramnios on the renin-angiotens?
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Losartan potassium as soon as possible [see Use in Specific Populations ( 8.1 )].
How many people are over 65 with Losartan?
Of the total number of patients receiving Losartan potassium in controlled clinical studies for hypertension, 391 patients (19%) were 65 years and over, while 37 patients (2%) were 75 years and over. In a controlled clinical study for renal protection in type 2 diabetic patients with proteinuria, 248 patients (33%) were 65 years and over. In a controlled clinical study for the reduction in the combined risk of cardiovascular death, stroke and myocardial infarction in hypertensive patients with left ventricular hypertrophy, 2857 patients (62%) were 65 years and over, while 808 patients (18%) were 75 years and over. No overall differences in effectiveness or safety were observed between these patients and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
How long does Losartan last?
Losartan has a shorter duration of action (length of time it works for) at lower dosages than valsartan. Research 1 indicates losartan lasts less than 24 hours at dosages of 25mg a day and 50mg a day. This may cause your blood pressure to rise at night if you take your dose in the morning.
How does angiotensin II blocker work?
They work by blocking a substance called angiotensin II that causes blood vessels to narrow (constrict). Blocking this substance means blood vessels can widen (dilate), which lowers blood pressure
What are the side effects of Valsartan?
Side effects that are common to both losartan and valsartan include diarrhea, dizziness, and fatigue
Can you take Valsartan while pregnant?
Neither losartan nor valsartan should be used during pregnancy and they are not recommended during breastfeeding.
Does Valsartan increase potassium?
Both losartan and valsartan can increase levels of potassium in your blood, which means you may require regular blood tests to monitor for this
Is Valsartan safe for high blood pressure?
Valsartan is FDA approved for high blood pressure and heart failure. It may also be given to reduce the risk of deaths in patients who have developed congestive heart failure after a heart attack. Although the side effects of losartan and valsartan are similar, some side effects, such as chest pain, insomnia, low blood sugar (hypoglycemia), ...
Is Valsartan a neprilysin inhibitor?
Valsartan is available in combination with sacubitril, a neprilysin inhibitor. The combination is called Entresto. Losartan is not available in combination with sacubitril.
